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1

A 20-Year-Old Man With Back Pain and Lower Extremity Weakness

Etherton, Mark R., Neagu, Martha R., Oakley, Derek H., Koch, Matthew J., Shin, John H., Frosch, Matthew P., Berkowitz, Aaron L., Dietrich, Jorg

Journal:

Year:

2015

Language:

english

File:

PDF, 273 KB

english, 2015

2

Reviewing hit discovery literature for difficult targets: glutathione transferase omega-1 as an example

Xie, Yiyue, Dahlin, Jayme L., Oakley, Aaron J, Casarotto, Marco G., Board, Philip G., Baell, Jonathan B.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

3

The 2.2 Å Crystal Structure of a Pocilloporin Pigment Reveals a Nonplanar Chromophore Conformation

Mark Prescott, Michael Ling, Travis Beddoe, Aaron J. Oakley, Sophie Dove, Ove Hoegh-Guldberg, Rodney J. Devenish, Jamie Rossjohn

Journal:

Year:

2003

Language:

english

File:

PDF, 538 KB

english, 2003

4

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

Oakley, Aaron J., Barrett, Susan, Peat, Thomas S., Newman, Janet, Streltsov, Victor A., Waddington, Lynne, Saito, Takehiko, Tashiro, Masato, McKimm-Breschkin, Jennifer L.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.14 MB

english, 2010

5

SAE Technical Paper Series [SAE International SAE 2001 World Congress - (MAR. 05, 2001)] SAE Technical Paper Series - Experimental Studies on Controlled Auto-ignition (CAI) Combustion of Gasoline in a 4-Stroke Engine

Oakley, Aaron, Zhao, Hua, Ladommatos, Nicos, Ma, Tom

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

6

A structural view of bacterial DNA replication

Oakley, Aaron J

Journal:

Protein Science

Year:

2019

Language:

english

File:

PDF, 2.11 MB

english, 2019

7

An automated method for the analysis of trabecular bone structure

Jean E. Aaron, David R. Johnson, John A. Kanis, Beverley A. Oakley, Paul O'Higgins, Stephen K. Paxton

Journal:

Computers and Biomedical Research

Year:

1992

Language:

english

File:

PDF, 979 KB

english, 1992

8

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1

Philip G. Board, Marjorie Coggan, Jean Cappello, Huina Zhou, Aaron J. Oakley, M.W. Anders

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 264 KB

english, 2008

9

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential

Marie A. Bogoyevitch, Ingrid Boehm, Aaron Oakley, Albert J. Ketterman, Renae K. Barr

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2004

Language:

english

File:

PDF, 381 KB

english, 2004

10

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

Jane E. Weber, Aaron J. Oakley, Angelika N. Christ, Alan G. Clark, John D. Hayes, Rhonda Hall, David A. Hume, Philip G. Board, Mark L. Smythe, Jack U. Flanagan

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 862 KB

english, 2010

11

Macromolecular Crystallography As A Tool For Investigating Drug, Enzyme And Receptor Interactions

Aaron J Oakley, Matthew Cj Wilce

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2000

Language:

english

File:

PDF, 312 KB

english, 2000

12

Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine

Stephen J. Watt, Aaron Oakley, Margaret M. Sheil, Jennifer L. Beck

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

13

Three-dimensional structure of (1,4)-β-d-mannan mannanohydrolase from tomato fruit

Richard Bourgault, Aaron J. Oakley, J. Derek Bewley, Matthew C.J. Wilce

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 664 KB

english, 2005

14

Structure and function of the bacterial mechanosensitive channel of large conductance

Aaron J. Oakley, Boris Martinac, Matthew C.J. Wilce, Boris Martinac

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 2.90 MB

english, 1999

15

The crystal structures of glutathione S-transferases isozymes 1–3 and 1–4 from Anopheles dirus species B

Aaron J. Oakley, Thasaneeya Harnnoi, Rungrutai Udomsinprasert, Kanya Jirajaroenrat, Albert J. Ketterman, Matthew C.J. Wilce

Journal:

Protein Science

Year:

2001

Language:

english

File:

PDF, 451 KB

english, 2001

16

Glutathione transferases: new functions

Journal:

Current Opinion in Structural Biology

Year:

2005

Language:

english

File:

PDF, 865 KB

english, 2005

17

Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site

Jamie Rossjohn, William J McKinstry, Aaron J Oakley, Denis Verger, Jack Flanagan, Gareth Chelvanayagam, Kian-Leong Tan, Philip G Board, Michael W Parker

Journal:

Year:

1998

Language:

english

File:

PDF, 881 KB

english, 1998

18

Glutathione transferases: a structural perspective

Journal:

Drug Metabolism Reviews

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

19

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution

Aaron J Oakley, Mario Lo Bello, Andrea Battistoni, Giorgio Ricci, Jamie Rossjohn, Hugo O Villar, Michael W Parker

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 1.11 MB

english, 1997

20

Mutations of gly to ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione

Mario Lo Bello, Marzia Nuccetelli, Ester Chiessi, Armin Lahm, Anna P Mazzetti, Andrea Battistoni, Anna M Caccuri, Aaron J Oakley, Michael W Parker, Anna Tramontano, Giorgio Federici, Giorgio Ricci

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 474 KB

english, 1998

21

The ligandin (non-substrate) binding site of human pi class glutathione transferase is located in the electrophile binding site (H-site)

Aaron J Oakley, Mario Lo Bello, Marzia Nuccetelli, Anna P Mazzetti, Michael W Parker

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 511 KB

english, 1999

22

Structures of thermolabile mutants of human glutathione transferase P1-1

Jamie Rossjohn, William J McKinstry, Aaron J Oakley, Michael W Parker, Gun Stenberg, Bengt Mannervik, Beatrice Dragani, Roberta Cocco, Antonio Aceto

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 411 KB

english, 2000

23

The structure of Aspergillus niger phytase PhyA in complex with a phytate mimetic

Aaron J. Oakley

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 629 KB

english, 2010

24

A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli

Mark D. Mulcair, Patrick M. Schaeffer, Aaron J. Oakley, Hannah F. Cross, Cameron Neylon, Thomas M. Hill, Nicholas E. Dixon

Journal:

Year:

2006

Language:

english

File:

PDF, 814 KB

english, 2006

25

The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

Lorien J. Parker, Sarah Ciccone, Louis C. Italiano, Alessandra Primavera, Aaron J. Oakley, Craig J. Morton, Nancy C. Hancock, Mario Lo Bello, Michael W. Parker

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.19 MB

english, 2008

26

Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases

Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, Aaron J. Oakley

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

27

Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase

Karin Loscha, Aaron J. Oakley, Bogdan Bancia, Patrick M. Schaeffer, Pavel Prosselkov, Gottfried Otting, Matthew C.J. Wilce, Nicholas E. Dixon

Journal:

Protein Expression and Purification

Year:

2004

Language:

english

File:

PDF, 371 KB

english, 2004

28

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

Aaron J Oakley, Mario Lo Bello, Anna Paola Mazzetti, Giorgio Federici, Michael W Parker

Journal:

Year:

1997

Language:

english

File:

PDF, 884 KB

english, 1997

29

Time to Face the Fats: What Can Mass Spectrometry Reveal about the Structure of Lipids and Their Interactions with Proteins?

Simon H. J. Brown, Todd W. Mitchell, Aaron J. Oakley, Huong T. Pham, Stephen J. Blanksby

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2012

Language:

english

File:

PDF, 493 KB

english, 2012

30

Bisdithiazolyl Radical Spin Ladders

Lekin, Kristina, Wong, Joanne W. L., Winter, Stephen M., Mailman, Aaron, Dube, Paul A., Oakley, Richard T.

Journal:

Inorganic Chemistry

Year:

2013

Language:

english

File:

PDF, 3.13 MB

english, 2013

31

Crossing the Insulator-to-Metal Barrier with a Thiazyl Radical Conductor

Mailman, Aaron, Winter, Stephen M., Yu, Xin, Robertson, Craig M., Yong, Wenjun, Tse, John S., Secco, Richard A., Liu, Zhenxian, Dube, Paul A., Howard, Judith A. K., Oakley, Richard T.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 346 KB

english, 2012

32

A Bimodal Oxobenzene-bridged Bisdithiazolyl Radical Conductor

Yu, Xin, Mailman, Aaron, Lekin, Kristina, Assoud, Abdeljalil, Dube, Paul A., Oakley, Richard T.

Journal:

Crystal Growth & Design

Year:

2012

Language:

english

File:

PDF, 3.67 MB

english, 2012

33

Crystal Structure of Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 Å Resolution: Dynamics of Catalytic Residues †,‡

Oakley, Aaron J., Klvaňa, Martin, Otyepka, Michal, Nagata, Yuji, Wilce, Matthew C. J., Damborský, Jiří

Journal:

Year:

2004

Language:

english

File:

PDF, 650 KB

english, 2004

34

Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp

Yin, Zhou, Kelso, Michael J., Beck, Jennifer L., Oakley, Aaron J.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

35

Structural and Binding Studies of the Cav1.1 β1A Subunit

Casarotto, Marco G., Karunasekara, Yamuna, Aditya, Shouvik, Cappello, Jean, Dulhunty, Angela F., Board, Philip G., Oakley, Aaron J., Norris, Nicole C.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 42 KB

english, 2014

36

Parathyroid gland hormones in the skeletal development of the ovine foetus: the effect of parathyroidectomy with calcium and phosphate infusion

Aaron, Jean E., Abbas, S.K., Colwell, A., Eastell, R., Oakley, Beverley A., Russell, R.G.G., Care, A.D.

Journal:

Bone and Mineral

Year:

1992

Language:

english

File:

PDF, 849 KB

english, 1992

37

DNA Replication Is the Target for the Antibacterial Effects of Nonsteroidal Anti-Inflammatory Drugs

Yin, Zhou, Wang, Yao, Whittell, Louise R., Jergic, Slobodan, Liu, Michael, Harry, Elizabeth, Dixon, Nicholas E., Kelso, Michael J., Beck, Jennifer L., Oakley, Aaron J.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.51 MB

english, 2014

38

Discovery of Lead Compounds Targeting the Bacterial Sliding Clamp Using a Fragment-Based Approach

Yin, Zhou, Whittell, Louise R., Wang, Yao, Jergic, Slobodan, Liu, Michael, Harry, Elizabeth J., Dixon, Nicholas E., Beck, Jennifer L., Kelso, Michael J., Oakley, Aaron J.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

39

Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray Crystallographic Studies of Dehalogenation of Brominated Substrates †,‡

Streltsov, Victor A., Prokop, Zbyněk, Damborský, Jiří, Nagata, Yuji, Oakley, Aaron, Wilce, Matthew C. J.

Journal:

Year:

2003

Language:

english

File:

PDF, 575 KB

english, 2003

40

Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme

UDOMSINPRASERT, Rungrutai, PONGJAROENKIT, Saengtong, WONGSANTICHON, Jantana, OAKLEY, Aaron J., PRAPANTHADARA, La-aied, WILCE, Matthew C. J., KETTERMAN, Albert J.

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 1.09 MB

english, 2005

41

Magneto-Optic Spectroscopy of a Protein Tetramer Binding Two Exciton-Coupled Chlorophylls

Hughes, Joseph L., Razeghifard, Reza, Logue, Mark, Oakley, Aaron, Wydrzynski, Tom, Krausz, Elmars

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 265 KB

english, 2006

42

Electronic and magnetic structure of neutral radical FBBO

Winter, Stephen M., Mailman, Aaron, Oakley, Richard T., Thirunavukkuarasu, Komalavalli, Hill, Stephen, Graf, David E., Tozer, Stanley W., Tse, John S., Mito, Masaki, Yamaguchi, Hiroshi

Journal:

Physical Review B

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

43

Exploring the Structure and Activity of Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26: Evidence for Product- and Water-Mediated Inhibition †,‡

Oakley, Aaron J., Prokop, Zbyněk, Boháč, Michal, Kmuníček, Jan, Jedlička, Tomáš, Monincová, Marta, Kutá-Smatanová, Ivana, Nagata, Yuji, Damborský, Jiří, Wilce, Matthew C. J.

Journal:

Year:

2002

Language:

english

File:

PDF, 405 KB

english, 2002

44

Binding Inhibitors of the Bacterial Sliding Clamp by Design

Wijffels, Gene, Johnson, Wynona M., Oakley, Aaron J., Turner, Kathleen, Epa, V. Chandana, Briscoe, Susan J., Polley, Mitchell, Liepa, Andris J., Hofmann, Albert, Buchardt, Jens, Christensen, Caspar, P

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.38 MB

english, 2011

45

Evidence for an Induced-Fit Mechanism Operating in Pi Class Glutathione Transferases †,‡

Oakley, Aaron J., Lo Bello, Mario, Ricci, Giorgio, Federici, Giorgio, Parker, Michael W.

Journal:

Year:

1998

Language:

english

File:

PDF, 153 KB

english, 1998

46

Efficient synthesis and antioxidant activity of coelenterazine analogues

Lu, Yueting, Hendra, Rudi, Oakley, Aaron J., Keller, Paul A.

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 663 KB

english, 2014

47

Multifunctional Role of Tyr 108 in the Catalytic Mechanism of Human Glutathione Transferase P1-1. Crystallographic and Kinetic Studies on the Y108F Mutant Enzyme †,‡

Lo Bello, Mario, Oakley, Aaron J., Battistoni, Andrea, Mazzetti, Anna P., Nuccetelli, Marzia, Mazzarese, Giampiero, Rossjohn, Jamie, Parker, Michael W., Ricci, Giorgio

Journal:

Year:

1997

Language:

english

File:

PDF, 239 KB

english, 1997

48

The Three-Dimensional Structure of the Human Pi Class Glutathione Transferase P1-1 in Complex with the Inhibitor Ethacrynic Acid and Its Glutathione Conjugate †,‡

Oakley, Aaron J., Rossjohn, Jamie, Lo Bello, Mario, Caccuri, Anna Maria, Federici, Giorgio, Parker, Michael W.

Journal:

Year:

1997

Language:

english

File:

PDF, 430 KB

english, 1997

49

Semiquinone-Bridged Bisdithiazolyl Radicals as Neutral Radical Conductors

Yu, Xin, Mailman, Aaron, Lekin, Kristina, Assoud, Abdeljalil, Robertson, Craig M., Noll, Bruce C., Campana, Charles F., Howard, Judith A. K., Dube, Paul A., Oakley, Richard T.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 734 KB

english, 2012

50

Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray Crystallographic Studies of Dehalogenation of Brominated Substrates

Streltsov, Victor A., Prokop, Zbyněk, Damborský, Jiří, Nagata, Yuji, Oakley, Aaron, Wilce, Matthew C. J.

Journal:

Year:

2003

Language:

english

File:

PDF, 56 KB

english, 2003